Why Biological Context Matters
Here's something that trips up a lot of data scientists moving into bioinformatics: biological datasets don't behave like typical machine learning problems. A correlation of 0.6 might be excellent in gene expression analysis but completely useless in predicting drug interactions.
The difference comes down to biological noise, experimental variability, and the fundamental messiness of living systems. Your models need to account for batch effects, population structure, and the fact that biological replicates often disagree in meaningful ways.
We teach you to think like a biologist when choosing features and like a computer scientist when implementing solutions. That combination is what makes computational biology work actually useful to lab researchers.
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